Proenkephalin-A Recombinant Protein

• Background:

  Proenkephalin-A is a secreted protein that belongs to the opioid neuropeptide precursor family. Proenkephalin-A is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Proenkephalin-A (114-133) and Proenkephalin-A (237-258) increase glutamate release in the striatum. Proenkephalin-A (114-133) decreases GABA concentration in the striatum.

• NCBI Gene ID:

  5179

• Swiss Prot:

  P01210

• Accession Number:

  P01210

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Immunology, Neuroscience, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  29.2 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Proenkephalin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Proenkephalin-A, Synenkephalin, Met-Enkephalin, Leu-Enkephalin, PENK

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3