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PBEF Recombinant Protein

CAT: 0223-92-711Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-711Size:0.05 mg
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Background
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are due to its role as a Nampt which can induce angiogenesis through upregulation of VEGF and VEGFR and secretion of MCP-1. Extracellular PBEF has been shown to increase inflammatory cytokines, such as TNF- alpha, IL-1 beta , IL-16, and TGF- beta 1. PBEF also increases the production of IL-6, TNF- alpha, and IL-1 beta in CD14+ monocyctes, macrophages, and dendritic cells, enhances the effectiveness of T cells.
CAS Number
9000-83-3
NCBI Gene ID
10135
Swiss Prot
P43490
Accession Number
P43490
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Chemokines & Cytokines, Immunology, Neuroscience, Obesity, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM HEPES, 150mM NaCl, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
57 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Nicotinamide phosphoribosyltransferase
NCBI Organism
Homo sapiens
Other Product Names
Pre-B cell-enhancing factor, Nicotinamide phosphoribosyltransferase, NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Visfatin, PBEF, PBEF1
Species
Human
Physical Properties
Lyophilized

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