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Nectin-3 Recombinant Protein

CAT: 0223-96-930Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-930Size:0.1 mg
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Background
Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559) . Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
CAS Number
9000-83-3
NCBI Gene ID
25945
Swiss Prot
NP_056295.1
Accession Number
Q9NQS3
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
64.3 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
CDw113
NCBI Organism
Homo sapiens
Background Reference 01
Mueller S., et al., 2003, J. Biol. Chem. 278:31251-31260.
Background Reference 02
Yu X., et al., 2009, Nat. Immunol. 10:48-57.
Other Product Names
CD113, Nectin-3, PVRL3
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized

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