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Oncomodulin-1 Recombinant Protein

CAT: 0223-91-225Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-225Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.
CAS Number
9000-83-3
NCBI Gene ID
654231
Swiss Prot
P0CE72
Accession Number
P0CE72
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Buffer
Lyophilized from a 0.2 um filtered solution of 50mM Tris, 100mM NaCl, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
14.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Oncomodulin
NCBI Organism
Homo sapiens
Other Product Names
Oncomodulin-1, OM, Parvalbumin Beta, OCM, OCM1, OCMN
Species
Human
Physical Properties
Lyophilized

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