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QAPRTase Recombinant Protein

CAT: 0223-91-237Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-237Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD (+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA) . The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
CAS Number
9000-83-3
NCBI Gene ID
23475
Swiss Prot
Q15274
Accession Number
Q15274
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Neuroscience, Obesity, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
33 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Quinolinate phosphoribosyltransferase
NCBI Organism
Homo sapiens
Other Product Names
Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating], Quinolinate Phosphoribosyltransferase [Decarboxylating], QAPRTase, QPRTase, QPRT
Species
Human
Physical Properties
Liquid

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