NTRK2 Recombinant Protein

• Background:

  Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”. NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.

• NCBI Gene ID:

  4915

• Swiss Prot:

  Q16620

• Accession Number:

  AAH31835

• Tag:

  C-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Neuroscience, Obesity, Signal Transduction

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  50 mM tris, 100 mM glycine, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  70.4 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Neurotrophic tyrosine kinase, receptor, type 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Allen S.J., et al., 1994, Neuroscience 60:825-834.

• Background Reference 02:

  Stoilov P., et al., 2002, Biochem. Biophys. Res. Commun. 290:1054-1065.

• Background Reference 03:

  Meakin S.O., et al., 1999, J. Biol. Chem. 274:9861-9870.

• Background Reference 04:

  Yeo G.S., et al., 2004, Nat. Neurosci. 7:1187-1189.

• Other Product Names:

  NTRK2, TRKB, GP145-TrkB

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3