Mesothelin Recombinant Protein

• Background:

  Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

• NCBI Gene ID:

  10232

• Swiss Prot:

  Q13421

• Accession Number:

  AAH09272

• Tag:

  N-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  59.6 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Mesothelin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.

• Background Reference 02:

  Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.

• Background Reference 03:

  Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.

• Background Reference 04:

  Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.

• Other Product Names:

  MSLN, Mesothelin, MPF

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3