MBL Recombinant Protein

• Background:

  Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind DNA.

• NCBI Gene ID:

  4153

• Swiss Prot:

  P11226

• Accession Number:

  AAH96179

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  24.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Mannose-binding lectin (protein C) 2, soluble (opsonic defect)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nauta A.J., et al., 2003, Eur. J. Immunol. 33:2853-2863.

• Background Reference 02:

  Hirano M., et al., 2005, J. Immunol. 175:3177-3185.

• Other Product Names:

  MBL, MBL2, MBP1, MBP-C, Collectin-1, COLEC1, HSMBPC, MBL2D, MBPD

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3