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MIF Recombinant Protein

CAT: 0223-40-689Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0223-40-689Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Macrophage migration inhibitory factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine, as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through CD74 and CD44, resulting in the secretion of TNF-a, IL-1, IL-6, IL-8, and various MMPs. The enzymatic activity of MIF is characterized by its ability to act as a tautomerase, capable of catalyzing the keto-to-enol isomerization of keto-phenylpyruvate and L-dopachrome. It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue. Insect cell-derived Recombinant Human MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag.
CAS Number
9000-83-3
NCBI Gene ID
4282
Swiss Prot
P14174
Type
Recombinant Proteins
Source
High-5 Insect cells
Field of Research
Immunology
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Macrophage migration inhibitory factor
NCBI Organism
Homo sapiens
Other Product Names
Macrophage Migration, Inhibitory Factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor
Species
Human, Mouse
Physical Properties
Lyophilized

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