Lumican Recombinant Protein

• Background:

  Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican, LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.

• NCBI Gene ID:

  176

• Swiss Prot:

  P51884

• Accession Number:

  NP_002336

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Other

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  37.5 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Aggrecan

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Onnerfjord P., et al., 2004, J. Biol. Chem. 279:26-33.

• Background Reference 02:

  Grover J., et al., 1995, J. Biol. Chem. 270:21942-21949.

• Other Product Names:

  LUM, Lumican, LDC, SLRR2D, KSPG lumican

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3