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KLRB1 Recombinant Protein

CAT: 0223-92-466Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-466Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Killer cell lectin-like receptor subfamily B, member 1 (KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha (1,3) Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
CAS Number
9000-83-3
NCBI Gene ID
3820
Swiss Prot
Q12918
Accession Number
Q12918
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology, Innate Immunity
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
45.6 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Killer cell lectin like receptor B1
NCBI Organism
Homo sapiens
Other Product Names
Killer cell lectin-like receptor subfamily B member 1, KLRB1, CLEC5B, NKRP1A, CD161, Natural killer cell surface protein P1A, NKR-P1A, HNKR-P1a, C-type lectin domain family 5 member B
Species
Human
Protein ID
767904139
Physical Properties
Lyophilized

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