IL1 R2 Recombinant Protein

• Background:

  Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB) . IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

• NCBI Gene ID:

  7850

• Swiss Prot:

  P27930

• Accession Number:

  NP_004624.1

• Tag:

  C-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Obesity, Signal Transduction, Stem Cell

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  50 mM tris, 100 mM glycine, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  64 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Interleukin 1 receptor, type II

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu C., et al., 1996, J. Biol. Chem. 271:20965-20972.

• Background Reference 02:

  Giri J.G., et al., 1994, J. Immunol. 153:5802-5809.

• Background Reference 03:

  Symons J.A., et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718.

• Background Reference 04:

  Orlando S., et al., 1997, J. Biol. Chem. 272:31764-31769.

• Other Product Names:

  CD121b, IL1RB, IL1R2, CDw121b

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3