IGF binding protein 6 Recombinant Protein

• Background:

  Insulin-like growth factors (IGFs) comprise a family of endocrine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.

• NCBI Gene ID:

  16012

• Swiss Prot:

  P47880

• Accession Number:

  P47880

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, EDTA, DTT, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  23.7 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Insulin-like growth factor binding protein 6

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, Igfbp6, IBP6, IGF binding protein 6

• Species:

  Mouse

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3