Inosine Triphosphatase Recombinant Protein

• Background:

  Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

• NCBI Gene ID:

  3704

• Swiss Prot:

  Q9BY32

• Accession Number:

  Q9BY32

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Obesity, Signal Transduction

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM TrisHCl, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  22.5 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Inosine triphosphatase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Inosine Triphosphate Pyrophosphatase, ITPase, Inosine Triphosphatase, Non-Canonical Purine NTP Pyrophosphatase, Non-Standard Purine NTP Pyrophosphatase, Nucleoside-Triphosphate Diphosphatase, Nucleoside-Triphosphate Pyrophosphatase, NTPase, Putative Oncogene Protein hlc14-06-p, ITPA, C20orf37

• Species:

  Human

• Protein ID:

  767932354

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3