PVRIG Recombinant Protein

• Background:

  Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

• NCBI Gene ID:

  79037

• Swiss Prot:

  Q6DKI7

• Accession Number:

  NP_076975.2

• Tag:

  Mouse IgG Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  40.7 kDa

• Applications Notes:

  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.7 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  PVR related immunoglobulin domain containing

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xu F., et.al. 2017, Cancer Immunol Immunother., 66 (10), 1367-1375.

• Background Reference 02:

  Zhu, Y., et.al. 2016, J. Exp. Med., 213,167-76.

• Other Product Names:

  C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, PVRIG, CD112 receptor

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3