Products for Research Use Only

VHR Recombinant Protein

CAT: 0223-91-590Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-91-590Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.
CAS Number
9000-83-3
NCBI Gene ID
1845
Swiss Prot
P51452
Accession Number
P51452
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Obesity, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
22.6 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Dual specificity phosphatase 3
NCBI Organism
Homo sapiens
Other Product Names
Dual specificity protein phosphatase 3, DUSP3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase, VHR
Species
Human
Physical Properties
Liquid