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BAI3 Recombinant Protein

CAT: 0223-91-387Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-387Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human Brain-Specific Angiogenesis Inhibitor 3 (BAI3) is a 177 kDa seven-span transmembrane (TM) protein, which is thought to be a member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids in size. It contains three distinct regions: an N-terminal extracellular domain (ECD) (aa25-883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type 1 repeat (aa296-508), and one GSP domain (aa 816-867) that is likely used to cleave the ECD from the membrane-bound receptor. There is one altermate splice form that shows a deletion of aa 643-665. Over aa 25-880, human BAI3 shares 98% aa identity with mouse BAI3. BAI3 has been reported primarily in the brain, but is also localized to lung, testis, and pancreas. It might be involved in angiogenesis inhibition and suppression of glioblastoma.
CAS Number
9000-83-3
NCBI Gene ID
577
Swiss Prot
O60242
Accession Number
O60242
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 5% Thehalose, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
97.51 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Adhesion G protein-coupled receptor B3
NCBI Organism
Homo sapiens
Other Product Names
Brain-Specific Angiogenesis Inhibitor 3, BAI3, KIAA0550
Species
Human
Protein ID
119632232
Physical Properties
Lyophilized

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