TNFRSF 14 Recombinant Protein

• Background:

  Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD) . Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

• NCBI Gene ID:

  8764

• Swiss Prot:

  Q92956

• Accession Number:

  NP_003811.2

• Tag:

  C-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Chemokines & Cytokines, Immunology, Infectious Disease

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  45.4 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.

• Background Reference 02:

  Mauri, D.N. et al., 1998, Immunity 8:21.

• Background Reference 03:

  Montgomery, R.I. et al., 1996, Cell 87:427.

• Background Reference 04:

  Cheung, T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.

• Other Product Names:

  TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2, CD270

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3