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HepaCAM Recombinant Protein

CAT: 0223-91-472Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-472Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416) . The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
CAS Number
9000-83-3
NCBI Gene ID
220296
Swiss Prot
Q14CZ8
Accession Number
Q14CZ8
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
24.09 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Hepatic and glial cell adhesion molecule
NCBI Organism
Homo sapiens
Other Product Names
Hepatocyte Cell Adhesion Molecule, Protein HepaCAM, HEPACAM
Species
Human
Physical Properties
Lyophilized

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