TIM3 Recombinant Protein

CAT: 0223-96-724Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-96-724Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1) -mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
CAS Number
9000-83-3
NCBI Gene ID
84868
Swiss Prot
Q8TDQ0
Accession Number
Q8TDQ0
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
46.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Hepatitis A virus cellular receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Monney, L. et al., 2002, Nature. 415: 536-41.
Background Reference 02
Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
Background Reference 03
Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.
Other Product Names
HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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