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TIM3 Antibody [2A6]

CAT: 0223-RF16106-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-RF16106-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1) . TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3) .
NCBI Gene ID
84868
Swiss Prot
Q8TDQ0
Accession Number
NP_116171
Host
Mouse
Reactivity
Human
Immunogen
TIM-3 antibody was raised against the extracellular domain of human TIM-3
Clonality
Monoclonal
Clone
2A6
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Immunology
Purification
TIM-3 Antibody is supplied as protein A purified IgG1.
Concentration
1 mg/mL
Buffer
TIM-3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TIM-3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1, k
Applications Notes
TIM-3 antibody can be used for ELISA starting at 0.1 μ g/mL. For Western blot start at 1 μ g/mL. For Immunocytochemistry start at 1 μ g/mL. For Immunofluorescence start at 10 μ g/mL. For Immunohistochemistry start at 5 μ g/mL. For Flow Cytometry start at 0.1 μ g/ml.
Symbol
HAVCR2
NCBI Official Name
Hepatitis A virus cellular receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Monney L, Sabatos CA, Gaglia JL, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of autoimmune disease. Nature 2002; 415:536-41.
Background Reference 02
Sakuishi K, Apetoh L, Sullivan JM, et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010; 207:2187–94.
Background Reference 03
Zhou Q, Munger ME, Veenstra RG, et al. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 2011; 117:4501–10.
Other Product Names
TIM-3 Antibody: Hepatitis A virus cellular receptor, HAVCR2, TIM3, CD366, KIM-3, TIMD3, TIMD-3
Tested Applications
ELISA, WB, IHC-P, ICC, IF, Flow
Protein ID
84868
Physical Properties
Liquid

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