Flt3-Ligand Recombinant Protein

• Background:

  Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.) . The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

• NCBI Gene ID:

  2323

• Swiss Prot:

  P49771

• Accession Number:

  NP_001191431.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Signal Transduction

• Purity:

  Greater than 98% by SDS-PAGE gel and HPLC analyses.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Flt3-Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Flt3-Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Flt3-Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Fms-related tyrosine kinase 3 ligand

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  FL, FLT3L, Fms-related tyrosine kinase 3 ligand, SL cytokine, Flt3 ligand

• Species:

  Human

• Protein ID:

  325197197

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3