Flt3 Ligand Recombinant Protein

• Background:

  Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand has no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.) . The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues.

• NCBI Gene ID:

  14256

• Swiss Prot:

  P49772

• Accession Number:

  NP_038548.3

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Flt3 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Flt3 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Flt3 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  FMS-like tyrosine kinase 3 ligand

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Ly72L, Flt3lg, Flt3l, Fms-related tyrosine kinase 3 ligand, SL cytokine, Flt3 ligand

• Species:

  Murine

• Protein ID:

  227430331

• Physical Properties:

  Lyophilized