Serpin F1 Recombinant Protein

• Background:

  Erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35) . Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.

• NCBI Gene ID:

  5176

• Swiss Prot:

  P36955

• Accession Number:

  NP_002606

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Immunology, Innate Immunity, Neuroscience, Obesity, Signal Transduction, Stem Cell

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  45.2 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Duh EJ., et al., 2002, Invest Ophthalmol Vis Sci 43 (3) : 821–9.

• Background Reference 02:

  Amaral J., et al., 2010, Invest Ophthalmol Vis Sci 51 (3) : 1318–26.

• Background Reference 03:

  Chen L., et al., 2006, Biochem. Biophys. Res. Commun. 348 (4) : 1288–95.

• Other Product Names:

  SERPINF1, Serpin F1, PEDF, PIG35, EPC-1

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3