Serpin E2 Recombinant Protein

• Background:

  SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1 (PN1) . SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA) . PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.

• NCBI Gene ID:

  5270

• Swiss Prot:

  P07093

• Accession Number:

  P07093-2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cell Cycle, Neuroscience

• Purity:

  >92% as determined by SDS-PAGE.

• Buffer:

  20 mM NaAc, 100 mM NaCl, PH6.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  42.7 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gloor S.M., et al., 1986, Cell 47:687-693.

• Background Reference 02:

  Scott R.W., et al., 1985, J. Biol. Chem. 260:7029-7034.

• Other Product Names:

  SERPINE2, Glia-derived nexin, GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Serpin E2, SerpinE2, PI7

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3