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Endocan Recombinant Protein

CAT: 0223-92-641Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-641Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Endothelial cell-specific molecule–1 (ESM-1) —so-called endocan—is a novel endothelium derived soluble dermatan sulfate proteoglycan (PG) that is constitutively expressed by endothelial cells in lungs and kidneys and can be detected in human blood. It is encoded by the ESM1 gene. The expression of this gene is regulated by several cytokines and growth factors, such as vascular endothelial growth factor. Inflammatory cytokines, such as interleukin (IL) -1 beta and tumor necrosis factor (TNF) - alpha, stimulate the upregulation of endocan mRNA and the secretion of endocan from endothelial cells. The binding of circulating endocan to leukocyte ligand for ICAM-1—Lymphocyte Function-associated Antigen-1 (LFA-1) and to leukocyte ligand for VCAM-1—Very Late Antigen-4 (VLA-4) is important in leukocyte adhesion and interaction with activated endothelium. Endocan is a key player in the regulation of major processes such as cell adhesion in inflammatory disorders and tumor progression.
CAS Number
9000-83-3
NCBI Gene ID
71690
Swiss Prot
Q9QYY7
Accession Number
Q9QYY7
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
19 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Endothelial cell-specific molecule 1
NCBI Organism
Mus musculus
Other Product Names
Endothelial cell-specific molecule 1, ESM-1, Esm1, Endocan
Species
Mouse
Physical Properties
Lyophilized

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