CRP Recombinant Protein

C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

9000-83-3

1401

P02741

NP_000558.2

His Tag

Recombinant Proteins

HEK293 cells

Homeostasis, Immunology, Signal Transduction

>95% as determined by SDS-PAGE.

200 mM Tris, 1M NaCl, pH8.0

Room Temp

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

24 kDa

This recombinant protein can be used for WB. For research use only.

C-reactive protein, pentraxin-related

Homo sapiens

Pepys MB, Hirschfield GM. 2003, J Clin Invest 111 (12) : 1805–12.

Lau DC., 2005, Am J Physiol Heart Circ Physiol 288 (5) : H2031–41.

CRP, C-reactive Protein

WB

Human