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SEMA4D Recombinant Protein

CAT: 0223-96-090Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-090Size:0.1 mg
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Background
Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.
CAS Number
9000-83-3
NCBI Gene ID
10507
Swiss Prot
Q92854
Accession Number
AAH54500
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
105.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
NCBI Organism
Homo sapiens
Background Reference 01
Delaire S, et al., 2001, J. Immunol. 166 (7) : 4348–54.
Background Reference 02
Ito Y, et al., 2006, EMBO Reports 7 (7) : 704–9.
Background Reference 03
Kumanogoh A, et al., 2000, Immunity 13 (5) : 621–31.
Background Reference 04
Ishida I, et al., 2007, Int. Immunol. 15 (8) : 1027–34.
Other Product Names
SEMA4D, C9orf164, CD100, FLJ33485, FLJ34282, FLJ39737, FLJ46484, M-sema-G, MGC169138, MGC169141, SEMAJ, coll-4, Semaphorin-4D
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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