CNTF Recombinant Protein

CAT: 0223-91-081Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-91-081Size:0.05 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
CAS Number
9000-83-3
NCBI Gene ID
1270
Swiss Prot
P26441
Accession Number
P26441
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines, Neuroscience, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 1mM Cysteine, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
22.93 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Ciliary neurotrophic factor
NCBI Organism
Homo sapiens
Other Product Names
Ciliary Neurotrophic Factor, CNTF
Species
Human
Protein ID
261385112
Physical Properties
Lyophilized

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