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CD44 Recombinant Protein

CAT: 0223-96-624Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-624Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs) . CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand) . CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.
CAS Number
9000-83-3
NCBI Gene ID
960
Swiss Prot
P16070
Accession Number
AAH04372
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Signal Transduction, Stem Cell, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
48.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD44 molecule (Indian blood group)
NCBI Organism
Homo sapiens
Background Reference 01
Goodison S., et al., 1999, MP, Mol. Pathol. 52 (4) : 189–96.
Background Reference 02
Hanley WD., et al., 2005, Cancer Res. 65 (13) : 5812–7.
Background Reference 03
Burdick MM., et al., 2006, J. Biol. Chem. 281 (20) : 13899–905.
Background Reference 04
Thomas SN., et al., 2008, J Biol Chem 283 (23) : 15647–55.
Other Product Names
CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, Epican
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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