CD44 Recombinant Protein

• Background:

  CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs) . CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand) . CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

• NCBI Gene ID:

  960

• Swiss Prot:

  P16070

• Accession Number:

  AAH04372

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Signal Transduction, Stem Cell, Other

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  22.9 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  CD44 molecule (Indian blood group)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Goodison S., et al., 1999, MP, Mol. Pathol. 52 (4) : 189–96.

• Background Reference 02:

  Hanley WD., et al., 2005, Cancer Res. 65 (13) : 5812–7.

• Background Reference 03:

  Burdick MM., et al., 2006, J. Biol. Chem. 281 (20) : 13899–905.

• Background Reference 04:

  Thomas SN., et al., 2008, J Biol Chem 283 (23) : 15647–55.

• Other Product Names:

  CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, Epican

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3