CD200 non-lytic Recombinant Protein

• Background:

  CD200, also known as OX-2, is a 45 kDa transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. CD200 knockout mice are characterized by increased macrophage number and activation and are predisposed to autoimmune disorders. In T cells, CD200 functions as a costimulatory molecule independent of the CD28 pathway. Several viruses encode CD200 homologs which are expressed on infected cells during the lytic phase. Like CD200 itself, viral CD200 homologs also suppress myeloid cell activity, enabling increased viral propagation.

• NCBI Gene ID:

  17470

• Swiss Prot:

  P17108

• Accession Number:

  NP_034948

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  CD200 antigen

• NCBI Organism:

  Mus musculus

• Other Product Names:

  OX-2 Membrane Glycoprotein, MOX2

• Species:

  Mouse

• Protein ID:

  111955312

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3