CCL4 Recombinant Protein

• Background:

  CCL4, (C-C motif chemokine 4; macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.

• NCBI Gene ID:

  6351

• Swiss Prot:

  Q9BQ51

• Accession Number:

  AAI04227

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Chemokines & Cytokines, Immunology

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Chemokine (C-C motif) ligand 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  C-C Motif Chemokine 4, Lymphocyte Activation Gene 1 Protein, LAG-1, Macrophage Inflammatory Protein 1beta, MIP-1beta, T Cell Activation Protein 2, ACT-2, Small-inducible Cytokine A4, PAT 744, Protein H400

• Species:

  Human

• Protein ID:

  74353782

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3