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CCL4 Antibody

CAT: 0223-7227-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7227-01Size:0.02 mg
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Background
CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.
NCBI Gene ID
6351
Swiss Prot
P13236
Accession Number
NP_002975
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
CCL4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (80%), Pig: (80%), Bovine: (85%)
Buffer
CCL4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCL4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 10 kDa
Fragment
IgG
Symbol
CCL4
NCBI Official Name
Chemokine (C-C motif) ligand 4
NCBI Organism
Homo sapiens
Background Reference 01
Baixeras E, Roman-Roman S, Jitsukawa S, et al. Cloning and expression of a lymphocyte activation gene (LAG-1) . Mol. Immunol. 1990; 27:1091-102.
Background Reference 02
Maurer M and von Stebut E. Macrophage inflammatory protein-1. Int. J. Biochem. Cell Biol. 2004; 36:1882-6.
Background Reference 03
Margolis LB, Glushakova S, Grivel JC, et al. Blockade of CC chemokine receptor 5 (CCR5) -tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines. J. Clin. Invest. 1998; 101:1876-80.
Other Product Names
CCL4 Antibody: ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4506845
Physical Properties
Liquid

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