CALR Recombinant Protein

• Background:

  Calreticulin is a multifunctional protein that acts as a major Ca (2+) -binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

• NCBI Gene ID:

  811

• Swiss Prot:

  P27797

• Accession Number:

  NP_004334

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Cancer, Immunology, Obesity, Signal Transduction

• Purity:

  ~90%

• Buffer:

  3

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• Calculated Molecular Weight:

  46 kDa (Calculated)

• Applications Notes:

  This recombinant protein can be used for WB, ELISA, MS.

• NCBI Official Name:

  Calreticulin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Horibe, T., Matsui, H., Tanaka, M., Nagai, H., Yamaguchi, Y., Kato, K. and Kikuchi, M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323 (1), 281-287 (2004)

• Other Product Names:

  RO, CRT, SSA, cC1qR, HEL-S-99n, CRTC, Calreticulin, CRP55, ERp60

• Tested Applications:

  ELISA, WB, MS

• Species:

  Human

• Protein ID:

  4757900

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3