BTNL2 Recombinant Protein

• Background:

  Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

• NCBI Gene ID:

  547431

• Swiss Prot:

  O95971

• Accession Number:

  NP_524574

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Butyrophilin-like 2

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Butyrophilin-like Protein 2

• Species:

  Mouse

• Protein ID:

  83721945

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3