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Axl Recombinant Protein

CAT: 0223-11-290Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-290Size:0.1 mg
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Background
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.
CAS Number
9000-83-3
NCBI Gene ID
102126361
Accession Number
XP_005589384.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Signal Transduction, Other
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
30.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.7 kDa. The protein migrates as 42-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
AXLreceptortyrosinekinase
NCBI Organism
Macaca fascicularis
Background Reference 01
Varnum B.C., et al., 1995, Nature 373:623-626.
Background Reference 02
Gallicchio M., et al., 2005, Blood 105:1970-1976.
Background Reference 03
Park I.K., et al., 2009, Blood 113:2470-2477.
Other Product Names
AXL, UFO
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized

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