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APRILmultimeric Recombinant Protein

CAT: 0223-90-229Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0223-90-229Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
CAS Number
9000-83-3
NCBI Gene ID
8741
Swiss Prot
P01375
Accession Number
O75888
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Chemokines & Cytokines
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 13
NCBI Organism
Homo sapiens
Other Product Names
ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand:
Species
Human, Mouse
Protein ID
4507599
Physical Properties
Lyophilized

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