AIMP1 Recombinant Protein

• Background:

  Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II) . AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.

• NCBI Gene ID:

  9255

• Swiss Prot:

  NP_004748.2

• Accession Number:

  AAH14051

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Chemokines & Cytokines, Growth Factors

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  35.2 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Barnett G., et al., 2000, Cancer Res. 60:2850-2857.

• Background Reference 02:

  Park S.G., et al., 1999, J. Biol. Chem. 274:16673-16676.

• Background Reference 03:

  Tandle A.T., et al., 2009, Exp. Cell Res. 315:1850-1859.

• Other Product Names:

  AIMP1, EMAP2, EMAPII, HLD3, SCYE1, p43, EMAP-2, EMAP-II, AIMP-1

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3