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AIMP1 Recombinant Protein

CAT: 0223-96-820Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-820Size:0.1 mg
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Background
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II) . AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
CAS Number
9000-83-3
NCBI Gene ID
9255
Swiss Prot
NP_004748.2
Accession Number
AAH14051
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines, Growth Factors
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
35.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
NCBI Organism
Homo sapiens
Background Reference 01
Barnett G., et al., 2000, Cancer Res. 60:2850-2857.
Background Reference 02
Park S.G., et al., 1999, J. Biol. Chem. 274:16673-16676.
Background Reference 03
Tandle A.T., et al., 2009, Exp. Cell Res. 315:1850-1859.
Other Product Names
AIMP1, EMAP2, EMAPII, HLD3, SCYE1, p43, EMAP-2, EMAP-II, AIMP-1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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