AIMP1 Antibody

• Background:

  AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1) . It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2) . AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3) . Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4) .

• NCBI Gene ID:

  9255

• Swiss Prot:

  Q12904

• Accession Number:

  NP_001135888

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  AIMP1 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken: (73%)

• Buffer:

  AIMP1 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  AIMP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist; this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

• Symbol:

  AIMP1

• Positive Control 2:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Positive Control 3:

  Cat. No. 1403 - Mouse Brain Tissue Lysate

• NCBI Official Name:

  Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Park SG, Jung KH, Lee JS, et al. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J. Biol. Chem. 1999; 274:16673–6.

• Background Reference 02:

  Park SG, Shin H, Shin YK, et al. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am. J. Pathol. 2005; 166:387–98.

• Background Reference 03:

  Quevillon S, Agou F, Robinson JC, et al. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 1997; 272:32573–9.

• Background Reference 04:

  Kwon HS, Park MC, Kim DG, et al. Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. J. Cell Sci. 2012; 125:4620-9.

• Other Product Names:

  AIMP1 Antibody: p43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  215490011

• Physical Properties:

  Liquid