Fetuin A Recombinant Protein

• Background:

  Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.

• NCBI Gene ID:

  197

• Swiss Prot:

  P02765

• Accession Number:

  NP_001613

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Cell Cycle, Immunology, Neuroscience, Obesity, Signal Transduction

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  38.2 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Alpha-2-HS-glycoprotein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jahnen-Dechent W., et al., 1994, Eur. J. Biochem. 226 : 59–69.

• Background Reference 02:

  Lee C., et al., 2009, Frontiers in Bioscience 14: 2911–2922.

• Background Reference 03:

  Heiss A., et al., 2008, J. Biol. Chem. 283 (21) : 14815–25.

• Background Reference 04:

  Jahnen-Dechent W., et al., 2008, J. Mol. Med. 86 (4) : 379–89.

• Other Product Names:

  AHSG, FETUA, Fetuin A

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3