Hydroxy-PP-Me

Hydroxy-PP-Me

• CAS Number: 833481-77-9
• UNSPSC Description: Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As2O3-induced apoptotic cell death compared with As2O3 alone[1][2].
• Target Antigen: Apoptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hydroxy-pp-me.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC1=CC=CC(C2=CN(C(C)C)C3=C2C(NC)=NC=N3)=C1
• Molecular Weight: 282.34
• References & Citations: [1]Tanaka M, et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May;3(5):e128.|[2]Jang M, et al. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported