12-Ethyl-9-hydroxycamptothecin

12-Ethyl-9-hydroxycamptothecin

• CAS Number: 119577-28-5
• UNSPSC Description: 12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].
• Target Antigen: Topoisomerase
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/12-ethyl-9-hydroxycamptothecin.html
• Purity: 99.89
• Solubility: DMSO : 83.33 mg/mL (ultrasonic)
• Smiles: O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(O)C=CC(CC)=C5N=C4C3=C2)=O
• Molecular Weight: 392.40
• References & Citations: [1]Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported