Maceneolignan A

• Description :

  Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae) . Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC50 of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC50 of 63.7 μM[1].

• UNSPSC :

  12352005

• Target :

  TNF Receptor

• Type :

  Natural Products

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/maceneolignan-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C2C([C@H]([C@H](C3=CC(OC)=C(C(OC)=C3)O)O2)C)=CC(/C=C/C)=C1

• Molecular Formula :

  C21H24O5

• Molecular Weight :

  356.41

• References & Citations :

  [1]Morikawa T, et al. Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells. J Nat Med. 2018 Mar;72 (2) :464-473.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [1967042-42-7]