N-Deshydroxyethyl Dasatinib-d8

• UNSPSC Description:

  N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].

• Target Antigen:

  Isotope-Labeled Compounds; Ligands for Target Protein for PROTAC

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Others;PROTAC

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=N1

• Molecular Weight:

  452.00

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1189998-96-6