N-Deshydroxyethyl Dasatinib-d8

N-Deshydroxyethyl Dasatinib-d8

• CAS Number: 1189998-96-6
• UNSPSC Description: N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].
• Target Antigen: Isotope-Labeled Compounds; Ligands for Target Protein for PROTAC
• Type: Isotope-Labeled Compounds
• Related Pathways: Others;PROTAC
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=N1
• Molecular Weight: 452.00
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported