AC-186

• Description :

  AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ac-186.html

• Purity :

  99.61

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  FC1=C(C=CC=C1)C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2

• Molecular Formula :

  C18H17F3O

• Molecular Weight :

  306.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4 (9) :1249-55.|[2]Jian-Nong Ma, et al. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1180-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERα; ERβ

• CAS Number :

  [1421854-16-1]