GCA-186

• Description:

  GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R (Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

• UNSPSC:

  12352005

• Target:

  HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/gca-186.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C(C(C)C)=C(N1COCC)CC2=CC(C)=CC(C)=C2)=O

• Molecular Formula:

  C19H26N2O3

• Molecular Weight:

  330.42

• References & Citations:

  [1]El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6- (trifluoromethylbenzyl) and 6- (fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim) . 2008;341 (1) :9-19. |[2]Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42 (22) :4500-4505.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  [149950-61-8]