MK2-IN-1

MK2-IN-1

• CAS Number: 1314118-92-7
• UNSPSC Description: MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein[1][2].
• Target Antigen: HSP; MAPKAPK2 (MK2)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;MAPK/ERK Pathway;Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/MK2-IN-1.html
• Purity: 99.04
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5
• Molecular Weight: 472.97
• References & Citations: [1]Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.|[2]Yan Zhang, et al. MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. Cell Rep. 2021 Nov 2;37(5):109949.Cell Rep. 2021 Nov 2;37(5):109949.|J Pharmacol Exp Ther. 2019 Aug;370(2):219-230.|Cell Death Dis. 2021 Oct 23;12(11):994.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported