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Spiradoline (mesylate)

CAT: 0804-HY-124959-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124959-01Size:1 mg
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Description
Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier[1][2].
CAS Number
87173-97-5
Product Name Alternative
U-62066 (mesylate)
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spiradoline-mesylate.html
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=C(C=CC(CC(N([C@H]2CC[C@@]3(C[C@@H]2N4CCCC4)OCCC3)C)=O)=C1)Cl.CS(O)(=O)=O
Molecular Formula
C23H34Cl2N2O5S
Molecular Weight
521.50
References & Citations
[1]Elena I Varlinskaya, et al. Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats. Neurobiol Stress. 2018 Sep 11;9:124-132.|[2]M-L G Wadenberg. A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist. CNS Drug Rev. Summer 2003;9 (2) :187-98.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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