Spiradoline

CAT: 0804-HY-106756Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-106756Size:1 Each

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Description

Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a Ki of 8.6 nM in guinea pig. The Ki values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier[1][2].

CAS Number

87151-85-7

Product Name Alternative

U-62066

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spiradoline.html

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=CC(CC(N([C@H]([C@H](C2)N3CCCC3)CC[C@]42CCCO4)C)=O)=CC=C1Cl

Molecular Formula

C22H30Cl2N2O2

Molecular Weight

425.39

References & Citations

[1]Elena I Varlinskaya, et al. Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague Dawley rats. Neurobiol Stress. 2018 Sep 11;9:124-132.|[2]M-L G Wadenberg. A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist. CNS Drug Rev. Summer 2003;9 (2) :187-98.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

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